15    Lewis, J. C.; Berman, A. M. Bergman, R. G.*; Ellman, J. A.* Rh(I)-Catalyzed Arylation of Heterocycles via C-H Bond Activation: Expanded Scope Through Mechanistic Insight. J. Am. Chem. Soc. 2008, 130, 2493-2500.


14    Berman, A. M.; Lewis, J. C.; Bergman, R. G.*; Ellman, J. A.* Rh(I)-Catalyzed Direct Arylation of Pyridines and Quinolines. J. Am. Chem. Soc. 2008, 130, 14926-14927.


13    Lewis, J. C.; Bergman, R. G.*; Ellman, J. A.* Direct Functionalization of Nitrogen Heterocycles via Rh-Catalyzed C-H Bond Activation. Acc. Chem. Res. 2008, 41, 1013-1025.


12    Tanuwidjaja, J.#; Peltier, H. M.; Lewis, J. C.; Schenkel, L. B.; Ellman, J. A.* One-Pot Microwave-Promoted Synthesis of Nitriles from Aldehydes via tert-Butanesulfinyl Imines. Synthesis 2007, 3385-3389.


11    Lewis, J. C.; Bergman, R. G.*; Ellman, J. A.* Rh(I)-Catalyzed Alkylation of Quinolines and Pyridines via C-H Activation. J. Am. Chem. Soc. 2007, 129, 5332.


10    Lewis, J. C.; Wu, J. Y.#; Bergman, R. G.*; Ellman, J. A.* Microwave-Promoted Rhodium-Catalyzed Arylation of Heterocycles via C-H Bond Activation. Angew. Chem. Int. Ed. 2006, 118, 1619-1621.


9    Zhang, Y.; Lewis, J. C.; Bergman, R. G.*; Ellman, J. A.*; Oldfield, E. NMR Shifts, Orbitals, and M...H-X Bonding in d8 Square Planar Metal Complexes. Organometallics 2006, 25, 3515-3519.


8    Wiedemann, S. H.; Lewis, J. C.; Bergman, R. G.*; Ellman, J. A.* Experimental and Computational Studies on the Mechanism of N-Heterocycle C-H Activation by Rh(I). J. Am. Chem. Soc. 2006, 128, 2452-2462.


7    Lewis, J. C.; Wu, J. Y.#; Ellman, J. A.*; Bergman, R. G.* Preagostic R-H Interactions and C-H Bond Functionalization: A Combined Experimental and Theoretical Investigation of Rh(I) Phosphinite Complexes. Organometallics 2005, 24, 5737-5746.


6    Lewis, J. C.; Wiedemann, S. H.; Bergman, R. G.*; Ellman, J. A.* Arylation of Heterocycles via Rhodium-catalyzed C-H Bond Functionalization. Org. Lett. 2004, 6, 35-38.

*corresponding author; #undergraduate


40    Andorfer, M. C.; Grob, J. E.; Hajdin, C. E.; Chael, J. R. #; Siuti, P.; Lilly, J.; Tan, K. L.*; Lewis, J. C.* Understanding Flavin-Dependent Halogenase Reactivity via Substrate Activity Profiling. ACS Catalysis. 2017, 7, 1897-1904.




39    Belsare, K.; Andorfer, M. C.; Cardenas, F. #; Chael, J. R. #; Park, H. J.; Lewis, J. C.* A Simple Combinatorial Codon Mutagenesis Method for Targeted Protein Engineering. ACS Synth. Biol. 2017, ASAP.



38    Upp, D. M.; Lewis, J. C.* Selective C-H Bond Functionalization Using Repurposed or Artificial Metalloenzymes. Curr. Opin. Chem. Biol. 2017, 37, 48-55.


37    Payne, J. T.; Andorfer, M. C.; Lewis, J. C.* Engineering Flavin-Dependent Halogenases. Meth. Enz. 2016, 575, 93-126.


36    Andorfer, M. C.; Park, H. J.; Vergara-Coll, J.#; Lewis, J. C.* Directed Evolution of RebH for Catalyst-Controlled Halogenation of Indole C-H Bonds. Chem. Sci. 2016, 7, 3720-3729.




35    Durak, L. J.; Payne, J. T.; Lewis, J. C.* Late-Stage Diversification of Biologically Active Molecules via Chemoenzymatic C-H Functionalization. ACS Catal. 2016, 6, 1451-1454.




34    Srivastava, P.; Yang, H.; Ellis-Guardiola, K.; Lewis, J. C.* Engineering a Dirhodium Artificial Metalloenzyme for Selective Olefin Cyclopropanation. Nat. Commun. 2015, 6, 7789.



33    Gu, Y.; Ellis-Guardiola, K.; Srivastava, P.; Lewis, J. C.* Preparation, Characterization,

and Reactivity of a Photocatalytic Artificial Enzyme. ChemBioChem. 2015, .



32    Payne, J. T.; Poor, C. B.; Lewis, J. C.* Directed Evolution of RebH for Site Selective Halogenation of Large, Biologically Active Molecules. Angew. Chem. Int. Ed. 2015, 54, 4226.



31    Lewis, J. C.* Metallopeptide Catalysts and Artificial Metalloenzymes Containing Unnatural Amino Acids. Curr. Opin. Chem. Biol. 2015, 25, 27-35.




30    Poor, C. B.; Andorfer, M. C.; Lewis, J. C.* Improving the Stability of the FAD-Dependent Halogenase RebH Using Directed Evolution.  ChemBioChem. 2014, 15, 1286-1289.




29    Zhang, C.; Srivastava, P.; Ellis-Guardiola, K.; Lewis, J. C.* Manganese Terpyridine Artificial Metalloenzymes for Benzylic Oxygenation and Olefin Epoxidation. Tetrahedron 2014, 70, 4245-4249.



28    Payne, J. T.; Lewis, J. C.* Upgrading Nature’s Tools: Expression Enhancement and Preparative Utility of the Halogenase RebH. Synlett 2014, 25, 1345-1349.


27    Durak, L. J. and Lewis, J. C.* Ir-Promoted, Pd-catalyzed Direct Arylation of Unactivated Arenes. Organometallics, 2014, 33, 620-623.





26    Yang, H.; Srivastava, P.; Zhang, C.; Lewis, J. C.* A General Method for Artificial Metalloenzyme Formation via Strain-Promoted Azide-Alkyne Cycloaddition. ChemBioChem. 2014, 15, 223-227.




25    Lewis, J. C.* Artificial Metalloenzymes and Metallopeptide Catalysts for Organic Synthesis. ACS Catal. (invited review) 2013, 3, 2954-2975.




24    Durak, L. and Lewis, J. C.* Transmetallation of Alkyl and Hydride Ligands From Cp*(PMe3)IrR1R2 to (cod)Pt/PdR3X. Organometallics. 2013, 32, 3153-3156.





23    Payne, J. T.; Andorfer, M. C.; Lewis, J. C. Regioselective Arene Halogenation Using the FAD-Dependent Halogenase RebH. Angew. Chemie. Int. Ed. 2013, 125, 5379-5382.





22    Zhong, Z.; Yang, H.; Zhang, C.; Lewis, J. C. Synthesis and Catalytic Activity of Amino Acids and Metallopeptides with Catalytically Active Metallocyclic Side Chains. Organometallics, 2012, 31, 7328-7331.

 

Patents

Undergraduate Studies

Graduate Studies

Postdoctoral Studies

Independent Studies (periodically updated)

5    Souers, A. J.; Wodka, D.; Gao, J.; Lewis, J. C.#; Vasudevan, A.; Gentles, R.; Brodjian, S.; Dayton, B.; Ogiela, C. A.; Fry, D.; Hernandez, L. E.; Marsh, K. C.; Collins, C. A.; Kym, P. R. Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg. Med. Chem. Lett. 2004, 14, 4873-4877.


4    Souers, A. J.; Wodka, D.; Gao, J.; Lewis, J. C.#; Vasudevan, A.; Brodjian, S.; Dayton, B.; Ogiela, C. A.; Fry, D.; Hernandez, L. E.; Marsh, K. C.; Collins, C. A.; Kym, P. R. Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 3. Bioorg. Med. Chem. Lett. 2004, 14, 4883-4886.


3    Ghosh, S.; Chan, J. M. W.#; Lea, C. R.; Meints, G. A.; Lewis, J. C.#; Tovian, Z. S.#; Flessner, R. M.; Loftus, T. C.#; Bruchhaus, I.; Kendrick, H.; Croft, S. L.; Kemp, R. G.; Kobayashi, S.; Nozaki, T.; Oldfield, E.* Effects of Bisphosphonates on the Growth of Entamoeba histolytica and Plasmodium Species in Vitro and in Vivo. J. Med. Chem. 2004, 47, 175-187.


2    Martin, M. B.; Sanders, J. M.; Kendrick, H.; de Luca-Fradley, K.; Yardley, V.; Lewis, J. C.#; Grimley, J. S.#; van Brussel, E. M.#; Olsen, J. R.#; Meints, G. A.; Burzyska, A.; Kararski, P.; Croft, S. L.; Oldfield, E.* A 3D-QSAR/CoMFA Study of the Activity of Bisphosphonates Against Trypanosoma brucei rhodesiense: Farnesyl Pyrophosphate Synthase as a Drug Target and Analysis of Drug Toxicity. J. Med. Chem. 2002, 45, 2904-2914.


1    Martin, M. B.; Grimley, J. S.#; Lewis, J. C.#; Heath, H. T. III; Bailey, B. N.; Kendrick, H.; Yardley, V.; Caldera, A.; Lira, R.; Urbina, J. A.; Moreno, S. N. J.; Docampo, R.; Croft, S.; Oldfield, E.* Bisphosphonates Inhibit the Growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: A Potential Route to Chemotherapy. J. Med. Chem. 2001, 44, 909-916.